Post-stroke depression (PSD) is the most
serious emotional disorder following stroke, affecting one-third of all stroke
survivors. Depression is associated with poor short-term recovery and long-term rehabilitation outcomes, excess disability, cognitive impairment, and mortality
in stroke survivors. The neuroanatomical model of PSD remains unclear despite
decade’s research.
A new model proposes that grey and white matter
lesions/ischemia in PSD disrupts the brain’s affective regulation network,
leading to hyperactivation of the limbic system and subsequent depressive
symptoms. The default mode network (DMN) is such a network that comprises brain
regions evolving in emotion regulation: ventromedial prefrontal cortex, ventral
anterior cingulate cortex, the posterior cingulate, precuneus, inferior lateral
parietal lobes, and parts of the temporal lobe. Read more>>>>>>>>>>>>>
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