Post-stroke depression (PSD) is the most
serious emotional disorder following stroke, affecting one-third of all stroke
survivors. Depression is associated with poor short-term recovery and long-term
rehabilitation outcomes, excess disability, cognitive impairment, and mortality
in stroke survivors. The neuroanatomical model of PSD remains unclear despitedecade’s research.
A new model proposes that grey and white matter
lesions/ischemia in PSD disrupts the brain’s affective regulation network,
leading to hyperactivation of the limbic system and subsequent depressive
symptoms. The default mode network (DMN) is such a network that comprises brain
regions evolving in emotion regulation: ventromedial prefrontal cortex, ventral
anterior cingulate cortex, the posterior cingulate, precuneus, inferior lateral
parietal lobes, and parts of the temporal lobe. These brain regions present
synchronic activation when the individual is in a state of wakeful rest and
deactivation when attentive to the outside world. Read more>>>>>>>>>
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